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NVP-BHG712
CAS No. 940310-85-0
NVP-BHG712 ( NVP BHG712 | NVP BHG-712 | NVP BHG 712 | BHG-712 | BHG712 )
产品货号. M16727 CAS No. 940310-85-0
NVP-BHG712 是一种特异性 EphB4 抑制剂，ED50 为 25 nM，可区分 VEGFR 和 EphB4 抑制。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥356 | 有现货 |
|
| 5MG | ￥583 | 有现货 |
|
| 10MG | ￥915 | 有现货 |
|
| 25MG | ￥1806 | 有现货 |
|
| 50MG | ￥3345 | 有现货 |
|
| 100MG | ￥5006 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NVP-BHG712
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述NVP-BHG712 是一种特异性 EphB4 抑制剂，ED50 为 25 nM，可区分 VEGFR 和 EphB4 抑制。
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产品描述NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.
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体外实验——
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体内实验Animal Model:Mice arrying chambers.Dosage:3, 10 and 30 mg/kg.Administration:P.O. daily for 4 days.Result:Significantly inhibited VEGF stimulated tissue formation and vascularization at doses of daily 3 mg/kg. Administration of 10 mg/kg/kg p.o. was sufficient to reverse VEGF enhanced tissue formation and vessel growth.
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同义词NVP BHG712 | NVP BHG-712 | NVP BHG 712 | BHG-712 | BHG712
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通路Tyrosine Kinase
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靶点Ephrin Receptor
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受体EphB4
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研究领域Cancer
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适应症——
化学信息
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CAS Number940310-85-0
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分子量503.489
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分子式C26H20F3N7O
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(NC3=C4C(N(C)N=C4)=NC(C5=CC=CN=C5)=N3)=C2
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化学全称4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Martiny-Baron G, et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010 Sep;13(3):259-67.
产品手册
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