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NVP-AEW541
CAS No. 475489-16-8
NVP-AEW541 ( AEW-541;AEW541;AEW 541;NVP AEW541 )
产品货号. M14585 CAS No. 475489-16-8
NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥478 | 有现货 |
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| 5MG | ￥786 | 有现货 |
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| 10MG | ￥1256 | 有现货 |
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| 25MG | ￥2317 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NVP-AEW541
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM.
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产品描述NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM; shows weak activity for closely related InsR (IC50=2.3 uM); inhibits IGF-IR autophosphorylation and abrogates IGF-I-mediated survival and colony formation in soft agar; inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas in vivo; orally bioavailable.Blood Cancer Phase 1 Clinical
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同义词AEW-541;AEW541;AEW 541;NVP AEW541
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通路Angiogenesis
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靶点IGF-1R
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受体FLT1;FLT3;IGF-1R;InsulinReceptor;Tek
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number475489-16-8
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分子量439.55
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分子式C27H29N5O
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 51 mg/mL
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SMILESNC1=C2C(N([C@H]3C[C@@H](CN4CCC4)C3)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
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化学全称7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. García-Echeverría C, et al. Cancer Cell. 2004 Mar;5(3):231-9.
2. Scotlandi K, et al. Cancer Res. 2005 May 1;65(9):3868-76.
3. Tanno B, et al. Clin Cancer Res. 2006 Nov 15;12(22):6772-80.
2. Scotlandi K, et al. Cancer Res. 2005 May 1;65(9):3868-76.
3. Tanno B, et al. Clin Cancer Res. 2006 Nov 15;12(22):6772-80.
产品手册
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