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HNMPA
CAS No. 132541-52-7
HNMPA ( —— )
产品货号. M27459 CAS No. 132541-52-7
HNMPA 是胰岛素受体酪氨酸激酶抑制剂，抑制人胰岛素受体的丝氨酸和酪氨酸自磷酸化。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥478 | 有现货 |
|
| 5MG | ￥689 | 有现货 |
|
| 10MG | ￥1191 | 有现货 |
|
| 25MG | ￥2568 | 有现货 |
|
| 50MG | ￥3848 | 有现货 |
|
| 100MG | ￥5630 | 有现货 |
|
| 500MG | ￥11907 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称HNMPA
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述HNMPA 是胰岛素受体酪氨酸激酶抑制剂，抑制人胰岛素受体的丝氨酸和酪氨酸自磷酸化。
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产品描述HNMPA is an inhibitor of insulin receptor tyrosine kinase and inhibits the serine and tyrosine autophosphorylation of human insulin receptor.(In Vitro):HNMPA reduces neuronal firing after GABA application and blocks GABA-dependent insulin inhibition. HNMPA has no effect on cyclic AMP-dependent protein kinase or protein kinase C activities.
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体外实验HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors.HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application.
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体内实验——
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同义词——
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通路Angiogenesis
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靶点IGF-1R
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受体DNMT3B|Parasite|antimalarial
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研究领域——
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适应症——
化学信息
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CAS Number132541-52-7
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分子量238.18
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分子式C11H11O4P
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纯度>98% (HPLC)
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溶解度——
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SMILESO=P(O)(O)C(O)C=1C=CC=2C=CC=CC2C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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KW-2450 free base
KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.
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Guvacine ethyl ester...
槟榔碱存在于坚果中。槟榔碱是从槟榔中分离出来的。槟榔碱是一种生物碱天然产物，存在于槟榔（槟榔棕榈（Areca catechu）的果实）中。
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Linsitinib
Linsitinib (ASP-7487, OSI-906) 是一种有效的、选择性的、口服活性的 IGF-1R/胰岛素受体双重抑制剂，IC50 分别为 35/75 nM。
