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NT157
CAS No. 1384426-12-3
NT157 ( —— )
产品货号. M28368 CAS No. 1384426-12-3
NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥899 | 有现货 |
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| 5MG | ￥1604 | 有现货 |
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| 10MG | ￥2414 | 有现货 |
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| 25MG | ￥4358 | 有现货 |
|
| 50MG | ￥6294 | 有现货 |
|
| 100MG | ￥8829 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NT157
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.
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产品描述NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.(In Vitro):NT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro.(In Vivo):NT157 suppressed androgen-responsive growth, delayed CRPC progression of LNCaP xenografts, and suppressed PC3 tumor growth alone and in combination with docetaxel.
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同义词——
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通路Angiogenesis
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靶点IGF-1R
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受体gp120/CD4;HIV;PKC
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研究领域——
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适应症——
化学信息
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CAS Number1384426-12-3
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分子量412.3
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分子式C16H14BrNO5S
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纯度>98% (HPLC)
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溶解度——
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SMILESOc1cc(CNC(=S)\C=C\c2cc(O)c(O)c(Br)c2)cc(O)c1O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ghoul A, et al. Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. Cancer Res. 2009 May 15;69(10):4260-9.
产品手册
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