PQ401

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PQ401 抑制 IGF-1R 结构域的自身磷酸化，IC50 小于 1 μM。

PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.

PQ401 (1, 5, 10, 25, and 50 μM; 3 days) inhibits proliferation of cultured MCF-7 cells grown in serum or IGF-I in MCF-7 cells.Twenty-four hours of treatment with 15 μM PQ401 induces caspase-mediated apoptosis. PQ401 inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1 μM. Cell Proliferation Assay Cell Line:Breast cancer cells, MCF-7 cellsConcentration:1, 5, 10, 25, and 50 μM Incubation Time:3 days Result:Significantly reduced proliferation (IC50, 8 μM) at concentrations in the range of 1 μM.Produced a dramatic reduction in cell number from pretreatment levels at concentrations >10 μM.

PQ401 (50 or 100 mg/kg; i.p.; thrice a week) results in a significant dose-dependent reduction in tumor growth over the course of the study. PQ401 reduces the growth rate of MCNeuA cells implanted into mice. Animal Model:Female mice were MCNeuA tumor cells Dosage:50 or 100 mg/kg Administration:Administered i.p. thrice a week; 24 days Result:Resulted in a significant dose-dependent reduction in tumor growth. Tumor growth in the animals treated with 100 mg/kg was 20% of that in the vehicle-treated controls. This dosing protocol was well tolerated by the animals.

PQ401 | PQ-401 | PQ 401

Angiogenesis

IGF-1R

IGF-1R

Cancer

——

196868-63-0

341.79

C18H16ClN3O2

>98% (HPLC)

DMSO: 32 mg/mL (93.62 mM)

O=C(NC1=CC(C)=NC2=CC=CC=C12)NC3=CC(Cl)=CC=C3OC

N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea

(-20℃)

With Ice Pack

≥ 2 years