NS3694 ( —— )

产品货号. M27510 CAS No. 426834-38-0

COA

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HNMR

HPLC

MSDS

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产品名称

NS3694
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.
产品描述

NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.(In Vitro):NS3694 (10, 50, and 100 μM) specifically inhibits cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9. In MCF-casp3 cells, NS3694 (10-100 μM) inhibits dose-dependently caspase 9, 3, and 7 processing, DFF45/ICAD, and PARP cleavage, and DEVDase activity and inhibits TNF-induced effector caspase activation and apoptosis.
同义词

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通路

Apoptosis
靶点

Apoptosis
受体

non-cleavable ADC linker;Alkyl-Chain
研究领域

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适应症

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1.Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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