NS309 ( NS309; NS-309; NS 309 )

产品货号. M18160 CAS No. 18711-16-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

NS309
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels).
产品描述

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.
同义词

NS309; NS-309; NS 309
通路

Immunology/Inflammation
靶点

ROS
受体

Potassium Channel
研究领域

Cardiovascular Disease
适应症

——

计算器

产品手册

关联产品

Cyfluthrin

Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests.
2-Isopropylphenol

2-Isopropylphenol has antioxidant property.
Sodium nitrite

Sodium nitrite is a myeloperoxidase inhibitor with IC50 of 1.3 μM.