NNK

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NNK 是一种致癌物质，也是一种主要的烟草特异性毒物。它抑制赖氨酰氧化酶的表达，赖氨酰氧化酶是一种肿瘤抑制因子。

NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.

NNK (100 pM; 0-60 min) stimulates activation of PKCα and MAPKs ERK1/2 that directly induce c-Myc phosphorylation.NNK (100 pM; 96 hours) enhances proliferation of cells expressing WT but not AA c-Myc mutant. Western Blot Analysis Cell Line:NCI-H82 cells Concentration:100 pM Incubation Time:0-60 min Result:Stimulated activation of PKCα and MAPKs ERK1/2 that directly induced c-Myc phosphorylation.Apoptosis Analysis Cell Line:H1299 lung cancer cells Concentration:100 pM Incubation Time:96 hours Result:Enhanced proliferation of cells expressing WT but not T58A/S62A c-Myc mutant.

——

Nicotine-derived nitrosamine ketone

Immunology/Inflammation

Lipoxygenase

LOX

——

——

64091-91-4

207.23

C10H13N3O2

>98% (HPLC)

DMSO:Soluble

CN(CCCC(c1cnccc1)=O)N=O

——

(-20℃)

With Ice Pack

≥ 2 years