• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

NKP-608

CAS No. 177707-12-9

NKP-608 ( NK 608;NK608 )

产品货号. M12675 CAS No. 177707-12-9

A non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥2098 有现货
50MG ¥8060 有现货
100MG ¥12798 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    NKP-608
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.
  • 产品描述
    A non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM; exhibits an anxiolytic-like effect in the social interaction and social exploration test in rats; orally active.Irritable Bowel Syndrome Discontinued
  • 同义词
    NK 608;NK608
  • 通路
    GPCR/G Protein
  • 靶点
    Neurokinin Receptor
  • 受体
    Neurokinin Receptor
  • 研究领域
    Other Indications
  • 适应症
    Irritable Bowel Syndrome

化学信息

  • CAS Number
    177707-12-9
  • 分子量
    619.98
  • 分子式
    C31H24ClF6N3O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    10 mM in DMSO
  • SMILES
    O=C(C1=CC=NC2=CC=CC=C12)N[C@@H]3C[C@@H](CC4=CC=C(Cl)C=C4)N(C(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)CC3
  • 化学全称
    4-Quinolinecarboxamide, N-[(2R,4S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(4-chlorophenyl)methyl]-4-piperidinyl]-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Gentsch C, et al. Behav Brain Res. 2002 Jul 18;133(2):363-8.
2. Vassout A, et al. Regul Pept. 2000 Dec 22;96(1-2):7-16.
3. Coulson FR, et al. Inflamm Res. 2002 Jul;51(7):317-23.
产品手册
关联产品
  • Hemokinin 1 (mouse)

    Hemokinin 1 (mouse) is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.

  • SB-222200

    SB-222200 is a selective, reversible, and competitive antagonist of the human NK-3 receptor(Ki=4.4 nM).

  • MLE-4901

    A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.