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NITD-916
CAS No. 1614262-83-7
NITD-916 ( NITD916 )
产品货号. M12349 CAS No. 1614262-83-7
NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥6707 | 有现货 |
|
| 10MG | ￥9153 | 有现货 |
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| 25MG | ￥12879 | 有现货 |
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| 50MG | ￥16038 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NITD-916
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM.
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产品描述NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb; shows MIC of 0.04 to 0.16 μM against MDR-Mtb strains, binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.
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同义词NITD916
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通路GPCR/G Protein
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靶点Antibacterial
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受体Antibacterial
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研究领域——
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适应症——
化学信息
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CAS Number1614262-83-7
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分子量311.43
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分子式C20H25NO2
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1(CCC(CC1)CC2=CC(=C(C(=O)N2)C3=CC=CC=C3)O)C
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化学全称6-((4,4-dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3.
2. McNeil MB, et al. Tuberculosis (Edinb). 2017 Dec;107:133-136.
2. McNeil MB, et al. Tuberculosis (Edinb). 2017 Dec;107:133-136.
产品手册
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