NIH-12848 ( NIH-12848;NCGC00012848-02. )

产品货号. M17694 CAS No. 959551-10-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

NIH-12848
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.
产品描述

NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor. NIH-12848 inhibited PI5P4Kγ with an IC50 of approximately 1 μM but did not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 is a potentially powerful tool for exploring the cell physiology of PI5P4Ks.
同义词

NIH-12848;NCGC00012848-02.
通路

GPCR/G Protein
靶点

Neurokinin Receptor
受体

PI5P4Kγ
研究领域

——
适应症

——

1. Clarke JH,et al.Biochem J. 2015 Mar 1;466(2):359-67.

计算器

产品手册

关联产品

QWF

Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.
Aprepitant

A potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM.
Neurokinin A(4-10)

Neurokinin A (4-10) is a tachykinin NK2 receptor agonist. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) was performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle.