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Fezolinetant
CAS No. 1629229-37-3
Fezolinetant ( ESN-364;ESN 364 )
产品货号. M12438 CAS No. 1629229-37-3
A potent, selective, orally active neurokinin-3 receptor (NK3R) antagonist with pIC50/pKi of 7.7/7.6.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1239 | 有现货 |
|
| 5MG | ￥2592 | 有现货 |
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| 10MG | ￥3775 | 有现货 |
|
| 25MG | ￥6205 | 有现货 |
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| 50MG | ￥8667 | 有现货 |
|
| 100MG | ￥11745 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Fezolinetant
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, selective, orally active neurokinin-3 receptor (NK3R) antagonist with pIC50/pKi of 7.7/7.6.
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产品描述A potent, selective, orally active neurokinin-3 receptor (NK3R) antagonist with pIC50/pKi of 7.7/7.6; exhibits high activity in LH inhibition, shows >2.5-log selectivity against NK1R and NK2R subtypes, proves >300-fold selective against related HPG axis receptors (KOR, GnRH, GnIH-R, GPR54).Other Indication Phase 2 Clinical
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同义词ESN-364;ESN 364
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通路GPCR/G Protein
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靶点Neurokinin Receptor
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受体Neurokinin Receptor
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number1629229-37-3
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分子量358.40
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分子式C16H15FN6OS
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 50 mg/mL 139.51 mM
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SMILESO=C(C1=CC=C(F)C=C1)N2[C@H](C)C3=NN=C(C4=NC(C)=NS4)N3CC2
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化学全称[(8R)-5,6-Dihydro-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl](4-fluorophenyl)methanone
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Hoveyda HR, et al. ACS Med Chem Lett. 2015 May 19;6(7):736-40.
2. Fraser GL, et al. Endocrinology. 2015 Nov;156(11):4214-25.
3. Fraser GL, et al. J Clin Endocrinol Metab. 2016 Feb;101(2):417-26.
2. Fraser GL, et al. Endocrinology. 2015 Nov;156(11):4214-25.
3. Fraser GL, et al. J Clin Endocrinol Metab. 2016 Feb;101(2):417-26.
产品手册
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