021-51111890
购物车（）
sales@molnova.cn
Fezolinetant
CAS No. 1629229-37-3
Fezolinetant ( ESN-364;ESN 364 )
产品货号. M12438 CAS No. 1629229-37-3
A potent, selective, orally active neurokinin-3 receptor (NK3R) antagonist with pIC50/pKi of 7.7/7.6.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1239 | 有现货 |
|
| 5MG | ￥2592 | 有现货 |
|
| 10MG | ￥3775 | 有现货 |
|
| 25MG | ￥6205 | 有现货 |
|
| 50MG | ￥8667 | 有现货 |
|
| 100MG | ￥11745 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Fezolinetant
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A potent, selective, orally active neurokinin-3 receptor (NK3R) antagonist with pIC50/pKi of 7.7/7.6.
-
产品描述A potent, selective, orally active neurokinin-3 receptor (NK3R) antagonist with pIC50/pKi of 7.7/7.6; exhibits high activity in LH inhibition, shows >2.5-log selectivity against NK1R and NK2R subtypes, proves >300-fold selective against related HPG axis receptors (KOR, GnRH, GnIH-R, GPR54).Other Indication Phase 2 Clinical
-
同义词ESN-364;ESN 364
-
通路GPCR/G Protein
-
靶点Neurokinin Receptor
-
受体Neurokinin Receptor
-
研究领域Other Indications
-
适应症Other Disease
化学信息
-
CAS Number1629229-37-3
-
分子量358.40
-
分子式C16H15FN6OS
-
纯度>98% (HPLC)
-
溶解度DMSO : ≥ 50 mg/mL 139.51 mM
-
SMILESO=C(C1=CC=C(F)C=C1)N2[C@H](C)C3=NN=C(C4=NC(C)=NS4)N3CC2
-
化学全称[(8R)-5,6-Dihydro-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl](4-fluorophenyl)methanone
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Hoveyda HR, et al. ACS Med Chem Lett. 2015 May 19;6(7):736-40.
2. Fraser GL, et al. Endocrinology. 2015 Nov;156(11):4214-25.
3. Fraser GL, et al. J Clin Endocrinol Metab. 2016 Feb;101(2):417-26.
2. Fraser GL, et al. Endocrinology. 2015 Nov;156(11):4214-25.
3. Fraser GL, et al. J Clin Endocrinol Metab. 2016 Feb;101(2):417-26.
产品手册
关联产品
-
Eledoisin Related Pe...
Eledoisin Related Peptide is a tachykinin receptor ligand and analogue of substance P. ERP can increase spontaneous activity and depolarizing neurons by decreasing membrane conductance.
-
Neurokinin A(4-10)(T...
Neurokinin A(4-10)(TFA) is an agonist of tachykinin NK2 receptor .
-
Talnetant
Talnetant is a selective competitive brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmission.
