NI-42 ( NI42;NI 42;BRPF1 inhibitor NI-42 )

产品货号. M12945 CAS No. 1884640-99-6

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

NI-42
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, selective and orally active BRPF1 bromodomain inhibitor with IC50 of 7.9 nM.
产品描述

A potent, selective and orally active BRPF1 bromodomain inhibitor with IC50 of 7.9 nM, with excellent selectivity over nonclass IV BRDs; weakly inhibits BRPF2 (BRD1), BRPF3, BRD9 and BRD4 (BD1) with IC50 of 48, 260, 310 and 4500 nM respectively, and no activity for ATAD2A/2B (IC50>100 uM); shows a modest (GI50=1-10 uM) and selective inhibition of proliferation of certain cancer lines, particularly those lines exhibiting monocytic lineage differentiation; a novel, structurally orthogonal chemical probe for the BRPFs suitable for cellular and in vivo studies.
同义词

NI42;NI 42;BRPF1 inhibitor NI-42
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1884640-99-6
分子量

353.40
分子式

C18H15N3O3S
纯度

>98% (HPLC)
溶解度

——
SMILES

O=S(C1=CC=C(C#N)C=C1)(NC2=CC(C=C(C)C(N3C)=O)=C3C=C2)=O
化学全称

4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)-benzenesulfonamide

1. Igoe N, et al. J Med Chem. 2017 Jan 26;60(2):668-680.

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产品手册

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