NBD-11021 ( NBD11021 )

产品货号. M11804 CAS No. 1427304-84-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

NBD-11021
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种小分子 CD4 完全拮抗剂，可阻断 gp120-CD4 相互作用。
产品描述

A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction; inhibits the CD4-dependent virus in a dose-dependent manner with IC50 of 2.4 uM; also weakly shows HIV-1 RT inhibition with IC50 of 43.4 uM; exhibits pan-neutralization activity against a panel of 56 Env-pseudotyped HIV-1 representing diverse subtypes of clinical isolates (IC50 as low as 270 nM).HIV Preclinical.
体外实验

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体内实验

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同义词

NBD11021
通路

Microbiology/Virology
靶点

HIV
受体

HIV
研究领域

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适应症

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CAS Number

1427304-84-4
分子量

444.978
分子式

C22H25ClN4O2S
纯度

>98% (HPLC)
溶解度

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SMILES

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化学全称

5-(4-chlorophenyl)-N-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)-1H-pyrrole-2-carboxamide

1. Curreli F, et al. J Med Chem. 2015 Sep 10;58(17):6909-6927.

计算器

产品手册

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