N-Acetyl-D-cysteine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

N-乙酰-D-半胱氨酸具有抗氧化活性，并通过与其硫醇基团反应清除ROS。

N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group.(In Vitro):Consistent with the known stereoselectivity of many biological processes, the unnatural D isomer of N-acetylcysteine failed to increase hepatic glutathione. Liver concentrations remained similar to control suggesting that the D isomer was unable to increase the rate of glutathione synthesis. The D isomer further differed from its L enantiomer in failing to increase the plasma concentration and the urinary excretion of inorganic sulfate. Congruent with these observations, much more N-acetyl-D-cysteine (47% of dose) was recovered unchanged in 24 hr urine than N-acetyl-L-cysteine (6.1% of dose).

N-Acetyl-D-cysteine (20 mM; 1 hour pretreatment; 12 hours) does not increase intracellular GSH levels, but GSH monoester does. D-NAC can not enhance hypoxic apoptosis. This demonstrate that GSH rather thanD-NAC or NAC is responsible for enhancing hypoxic apoptosis.

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(S)-2-Acetamido-3-mercaptopropanoic acid

Immunology/Inflammation

ROS

Topo I|Topo II|Apoptosis

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26117-28-2

163.19

C5H9NO3S

>98% (HPLC)

In Vitro:?H2O : 250 mg/mL (1531.96 mM)

CC(=O)N[C@H](CS)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years