Millepachine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.

Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.(In Vitro):Millepachine (2-8 μM; 24 h) inhibits ATP-binding cassette transporter activity in A2780CP cells. Millepachine (2-8 μM; 24 or 48 h) induces significant G2/M arrest and apoptosis of cisplatin-sensitive A2780S and cisplatin-resistant A2780CP cells. The percentage of cells in the G2/M fraction increased from 15.99% in vehicle cells to 24.93%, 60.67%, and 77.31% at dose of 2, 4, and 8 μM in A2780S cells, respectively. Millepachine (2-8 μM; 24 h) decreases topoisomerase II levels in A2780S and A2780CP cells. Millepachine (1.25-20 μM; 48 h) remarkably inhibits the proliferation of cisplatin-resistant A2780CP cells with an IC50 of 4 μM.(In Vivo):Millepachine (20 mg/kg; i.v.) reduced tumor volume and tumor weight with the inhibitory rate of 73.21% and 65.58% in A2780S and A2780CP xenograft models, respectively. Millepachine does not induce acquired drug resistance in an excised A2780S xenograft model.

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Apoptosis

Apoptosis

NO

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1393922-01-4

350.4

C22H22O4

>98% (HPLC)

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CC(C)(C=Cc1c(cc2)OC)Oc1c2C(/C=C/c(cc1)ccc1OC)=O

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(-20℃)

With Ice Pack

≥ 2 years