MeTC7

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MeTC7 是一种维生素 D 受体 (VDR) 拮抗剂。MeTC7 具有有效的 VDR 抑制活性，IC50 值为 2.9 μM。MeTC7 显示出良好的抗肿瘤作用。

MeTC7 is a Vitamin-D receptor (VDR) antagonist. MeTC7 has potent VDR inhibition activity with an IC50 value of 2.9 μM. MeTC7 shows good antitumor effects.

MeTC7 (compound 5) shows potent VDR inhibition activity with an IC50 value of 2.9 μM.MeTC7 disrupts the VDR-Ligand-binding domain in Silico.MeTC7 (250 nM; 18 h) suppresses RXRα and Importin-4 expressions in the ovarian cancer cell-line.MeTC7 (250 nM; 18 h) inhibits the viability of ovarian cancer cells and induces PARP1 cleavage.Western Blot Analysis Cell Line:2008 cells Concentration:250 nM Incubation Time:18, 12 h Result: Reduced the expression of RXR-α, Importin-4 and increased cleaved PARP1 expression in 2008 cells.Cell Viability Assay Cell Line:SKOV-3, IGROV-1, CAOV-3, OVCAR-3, OVCAR-8, and 2008 ovarian cancer cell-lines Concentration:0, 0.25, 0.5, 0.75, 1.0, 1.25 μM Incubation Time:24 h Result:Reduced the viability of SKOV-3, IGROV-1, CAOV-3, OVCAR-3, OVCAR-8, and 2008 ovarian cancer cell-lines.

MeTC7 (compound 5) (i.p.; 10 mg/kg) reduces the growth of the spontaneous transgenic TH-MYCN neuroblastoma and xenografts in vivo.Animal Model:Mice Dosage:10 mg/kg Administration:IP Result:Reduced the growth of xenografts derived from ovarian cancer, medulloblastoma, and pancreatic cancer cells.Inhibited the growth of neuroblastoma cells and Xenografts.Reduced MYCN expression and blocked the growth of TH-MYCN transgene-driven spontaneous neuroblastoma.

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Metabolic Enzyme/Protease

Vitamin

Vitamin

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1817841-22-7

618.65

C32H48BrN3O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 16.67 mg/mL (26.95 mM; 超声助溶 (<60°C)

O=C1N2C34[C@@]([C@]5(C)C(N2C(=O)N1C)(C=C3)C[C@@H](OC(CBr)=O)CC5)(CC[C@@]6(C)[C@]4(CC[C@@]6([C@@H](CCCC(C)C)C)[H])[H])[H]

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(-20℃)

With Ice Pack

≥ 2 years