Marbostat-100
CAS No. 1876450-69-9
Marbostat-100 ( Marbostat 100 )
产品货号. M12908 CAS No. 1876450-69-9
Marbostat-100 is a potent, selective HDAC6 inhibitor with Ki of 0.7 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
100MG | 获取报价 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Marbostat-100
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Marbostat-100 is a potent, selective HDAC6 inhibitor with Ki of 0.7 nM.
-
产品描述Marbostat-100 is a potent, selective HDAC6 inhibitor with Ki of 0.7 nM, displays >200-fold selectivity over HDAC1-5, and HDAC7-10; Marbostat-100 is a more selective HDAC6i than previously established well-characterized compounds; Marbostat-100 is well tolerated by mice and demonstrates in vivo anti-inflammatory activity against collagen type II induced arthritis, represents a most selective known HDAC6i and the possibility for clinical evaluation of a HDAC isoform-specific drug.
-
同义词Marbostat 100
-
通路Cell Cycle/DNA Damage
-
靶点HDAC
-
受体HDAC
-
研究领域——
-
适应症——
化学信息
-
CAS Number1876450-69-9
-
分子量404.43
-
分子式C22H20N4O4
-
纯度>98% (HPLC)
-
溶解度——
-
SMILES——
-
化学全称N-Hydroxy-4-((4-methyl-3,5-dioxo-3,4,5,6-tetrahydro-2,6-methano[1,3]diazocino[5,6-b]indol-11(1H)-yl)methyl)benzamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Sellmer A, et al. J Med Chem. 2018 Apr 6. doi: 10.1021/acs.jmedchem.7b01593.
产品手册
关联产品
-
CHR-3996
CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.
-
Crebinostat
Crebinostat is a novel cognitive enhancer that inhibits class I HDAC/1/2/3.
-
NSC 3852
NSC 3852 is a potent inhibitor of histone deacetylase.