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CHR-3996
CAS No. 1256448-47-1
CHR-3996 ( Nanatinostat;CHR3996;VRx-3996;Tractinostat )
产品货号. M11049 CAS No. 1256448-47-1
CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3856 | 有现货 |
|
| 50MG | ￥16119 | 有现货 |
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| 100MG | ￥24138 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CHR-3996
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.
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产品描述CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3; displays little to no activity against HDAC5 and HDAC6 (IC50=200-2000 nM); demonstrates growth inhibition of HCT116 cells with GI50 of 72 nM, shows efficacy in human tumor xenograft and exhibits good activity in combination with other anticancer agents.Blood Cancer Phase 2 Clinical
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同义词Nanatinostat;CHR3996;VRx-3996;Tractinostat
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number1256448-47-1
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分子量394.41
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分子式C20H19FN6O2
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C1=CN=C(N2C[C@]3([H])[C@@H](NCC4=NC5=CC=C(F)C=C5C=C4)[C@]3([H])C2)N=C1)NO
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化学全称2-[(1R,5S,6s)-6-{[(6-fluoroquinolin-2-yl)methyl]amino}-3-azabicyclo[3.1.0]hexan-3-yl]-N-hydroxypyrimidine-5-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Moffat D, J Med Chem. 2010 Dec 23;53(24):8663-78.
2. Banerji U, et al. Clin Cancer Res. 2012 May 1;18(9):2687-94.
3. Smith EM, et al. Oncotarget. 2015 Jul 10;6(19):17314-27.
2. Banerji U, et al. Clin Cancer Res. 2012 May 1;18(9):2687-94.
3. Smith EM, et al. Oncotarget. 2015 Jul 10;6(19):17314-27.
