Madecassoside ( Asiaticoside A )

产品货号. M18455 CAS No. 34540-22-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Madecassoside
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Madecassoside 是从 Centella asitica (L.) 中提取的五环三萜，具有抗炎、抗氧化和抗衰老活性。
产品描述

Madecassoside is a pentacyclic triterpene extracted from Centella asitica (L.) with anti-inflammatory, anti-oxidative and anti-aging activities.
体外实验

Cell Viability Assay Cell Line:HUVECs Concentration:10, 30, 100 μmol/L Incubation Time:12 h Result:Increased cell viability to 68.9% and 78.3%, with concentration of 30 and 100 μmol/L, respectively.Western Blot Analysis Cell Line:HUVECs Concentration:10, 30, 100 μmol/L Incubation Time:12 h Result:Inhibited phosphorylation in p38 MAPK.
体内实验

Animal Model:Focal cerebral ischemia reperfusion injury in Sprague Dawley rats Dosage:6, 12, 24 mg/kg Administration:Intravenous injection Result:Reduced neurological deficit, infarct area, brain damage and neuronal apoptosis.Animal Model:Lipopolysaccharide-induced neurotoxicity in Sprague-Dawley rats Dosage:30-120 mg/kg for 14 days Administration:Intraperitoneal injection Result:Reduced LPS-induced cognitive impairment and imflammatory cytokine, promoted Nrf2 pathway at concentration of 120 mg/kg.
同义词

Asiaticoside A
通路

Others
靶点

Other Targets
受体

Others
研究领域

Others-Field
适应症

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CAS Number

34540-22-2
分子量

975.12
分子式

C48H78O20
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 9.8 mg/mL; 10.05 mM
SMILES

[C@@H]1([C@@H](CC[C@@]2(CC[C@@]3([C@@]4(C[C@H]([C@H]5[C@]([C@H]([C@@H](C[C@@]5([C@H]4CC=C3[C@H]12)C)O)O)(C)CO)O)C)C)C(=O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O)O)O)O)O)C)C
化学全称

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