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AZ13705339
CAS No. 2016806-57-6
AZ13705339 ( AZ-13705339 | AZ 13705339 )
产品货号. M27853 CAS No. 2016806-57-6
AZ13705339 是一种有效的选择性 PAK1 抑制剂，IC50 为 0.33 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥316 | 有现货 |
|
| 5MG | ￥518 | 有现货 |
|
| 10MG | ￥794 | 有现货 |
|
| 25MG | ￥1798 | 有现货 |
|
| 50MG | ￥2876 | 有现货 |
|
| 100MG | ￥4633 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AZ13705339
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AZ13705339 是一种有效的选择性 PAK1 抑制剂，IC50 为 0.33 nM。
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产品描述AZ13705339 is a potent and selective PAK1 inhibitor with IC50 of 0.33 nM.(In Vitro):AZ13705339 (300 nM) prevents Siglec-8 binding-induced eosinophil death. In Namalwa cells, AZ13705339 (1 μM) inhibits αIgM-controlled but not PMA-induced adhesion.(In Vivo):In rats, AZ13705339 (100 mg/kg, p.o.) exhibits moderate clearance and Cmax of 7.7 μM.
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体外实验AZ13705339 (1 μM) inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells.AZ13705339 (300 nM, 30 min) prevents Siglec-8 engagement-induced eosinophil death.
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体内实验AZ13705339 (100 mg/kg, P.O.) has moderate clearance and oral Cmax of 7.7 μM in rats.
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同义词AZ-13705339 | AZ 13705339
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number2016806-57-6
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分子量629.76
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分子式C33H36FN7O3S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 250 mg/mL (396.98 mM)
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SMILESCCS(=O)(=O)c1cc(Nc2ncc(F)c(n2)N(Cc2ccccc2C#N)c2cc(CO)ccc2C)ccc1N1CCN(C)CC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Andrew F Ducruet , et al. GM1485, a Nonimmunosuppressive Immunophilin Ligand, Promotes Neurofunctional Improvement and Neural Regeneration Following Stroke. J Neurosci Res. 2012 Jul;90(7):1413-23.
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