MPT0G211

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MPT0G211 is a novel potent, selective HDAC6 inhibitor with IC50 of 0.291 nM.

MPT0G211 is a novel potent, selective HDAC6 inhibitor with IC50 of 0.291 nM, displays >1,000-fold selectivity over other HDAC isoforms; significantly inhibits tau phosphorylation on Ser396, Ser404, and phosphorylated tau (p-tau) aggregation, significantly attenuates apoptosis induced by p-tau, inhibits HDAC6/Hsp90 binding and causes subsequent proteasomal degradation of polyubiquitinated proteins; ameliorates learning and memory impairment in animal models of Alzheimer's disease, reduces the amount of phosphorylated tau in the hippocampal CA1 region; also demonstrates antiproliferative activity against human multiple myeloma RPMI 8226, U266, and NCI-H929 cells with no effect on normal bone marrow cells.

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Cell Cycle/DNA Damage

HDAC

HDAC

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2151853-97-1

293.33

C17H15N3O2

>98% (HPLC)

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C1=CC2=C(C(=C1)NCC3=CC=C(C=C3)C(=O)NO)N=CC=C2

N-hydroxy-4-((quinolin-8-ylamino)methyl)benzamide

(-20℃)

With Ice Pack

≥ 2 years