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MPT0E028
CAS No. 1338320-94-7
MPT0E028 ( MPT0 E028 )
产品货号. M11358 CAS No. 1338320-94-7
MPT0E028 (MPT 0E028) is a potent HDAC inhibitor that inhibits nuclear HDAC activity with IC50 of 11.1 nM in HeLa cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1750 | 有现货 |
|
| 50MG | ￥8060 | 有现货 |
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| 100MG | ￥14094 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MPT0E028
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MPT0E028 (MPT 0E028) is a potent HDAC inhibitor that inhibits nuclear HDAC activity with IC50 of 11.1 nM in HeLa cells.
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产品描述MPT0E028 (MPT 0E028) is a potent HDAC inhibitor that inhibits nuclear HDAC activity with IC50 of 11.1 nM in HeLa cells, 9-30 times more potent than SAHA; inhibits class I HDAC1, HDAC2, and class Iib HDAC6 with IC50 of 53, 106, and 29.5 nM, respectively, weakly inhibits HDAC8 (IC50=2.5 uM), but not for HDAC4 (IC50>10 uM); inhibits the growth of HCT116 and MDA-MB-231 cells with IC50 of 0.09 and 0.19 uM; inhibits HCT116 tumor xenograft in vivo without significant adverse effects, shows stronger anti-cancer efficacy than SAHA.Solid Tumors Phase 1 Clinical
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同义词MPT0 E028
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC
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研究领域Cancer
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适应症Solid Tumors
化学信息
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CAS Number1338320-94-7
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分子量344.39
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分子式C17H16N2O4S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(NO)/C=C/C1=CC2=C(N(S(=O)(C3=CC=CC=C3)=O)CC2)C=C1
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化学全称(E)-N-hydroxy-3-(1-(phenylsulfonyl)indolin-5-yl)acrylamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Huang HL, et al. PLoS One. 2012;7(8):e43645.
2. Chen MC, et al. Cell Death Dis. 2013 Sep 19;4:e810.
3. Chen CH, et al. Clin Cancer Res. 2014 Mar 1;20(5):1274-1287.
4. Huang HL, et al. Oncotarget. 2015 Mar 10;6(7):4976-91.
2. Chen MC, et al. Cell Death Dis. 2013 Sep 19;4:e810.
3. Chen CH, et al. Clin Cancer Res. 2014 Mar 1;20(5):1274-1287.
4. Huang HL, et al. Oncotarget. 2015 Mar 10;6(7):4976-91.
产品手册
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