MMAD ( MMAD, Demethyldolastatin 10; Monomethyl Dolastatin 10 )

产品货号. M18216 CAS No. 203849-91-6

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HPLC

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产品名称

MMAD
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
产品描述

MMAD, also known as Monomethyl auristatin D, is a highly potent tubulin inhibitor. MMAD is one of the auristatins, which are used as antibody drug conjugates (ADCs).
同义词

MMAD, Demethyldolastatin 10; Monomethyl Dolastatin 10
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

Microtubule/Tubulin
研究领域

Cancer
适应症

——

CAS Number

203849-91-6
分子量

771.06
分子式

C41H66N6O6S
纯度

98%
溶解度

DMSO : 24.5 mg/mL 31.77 mM;
SMILES

O=C(N[C@@H](Cc1ccccc1)c2nccs2)[C@H](C)[C@@H](OC)[C@@H]3CCCN3C(=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C
化学全称

(S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

1.Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9.

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