MLS000544460

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MLS000544460 是一种高度选择性和可逆的 Eya2 磷酸酶抑制剂，Kd 为 2.0 μM，IC50 为 4 μM。MLS000544460 抑制 Eya2 磷酸酶介导的细胞迁移，并具有抗癌活性。

MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity.

MLS000544460 does not bind Eya3 phosphatase (ED). MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells. When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg2+, it binds MLS000544460 with a higher affinity (Kd=0.80 μM), indicating that this class of compounds does not require Mg2+ for its interaction with the Eya2 ED.

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Metabolic Enzyme/Protease

Phosphatase

Phosphatase

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352336-36-8

341.36

C17H12FN3O2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (366.18 mM; 超声助溶 )

Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1

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(-20℃)

With Ice Pack

≥ 2 years