Voclosporin ( —— )

产品货号. M33531 CAS No. 515814-01-4

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Voclosporin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Voclosporin (ISAtx-247) 是一种钙调神经磷酸酶 (CN; PP2B) 抑制剂。
产品描述

Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor.
体外实验

This novel semi-synthetic calcineurin (CN) inhibitor is designated Voclosporin (ISATX247). The efficacy of Voclosporin as an immunosuppressive agent is examined using an in vitro calcineurin assay. Voclosporin (ISATX247) is a calcineurin inhibitor that has shown more potency than Cyclosporine in vitro.
体内实验

All animals tolerate Voclosporin (ISATX247) and Cyclosporine A (CsA) very well. There are no severe adverse effects associated with either drug. In the Voclosporin group, all animals except 1 have diarrhea of different durations during the study (mean 2.3 days, range 2 to 7 days). This differs from the CsA and the control groups, where no animals have diarrhea. Mean weight loss at the end of the study is slightly higher in the Voclosporin group than in the CsA and control groups (3.4% vs 2.0% and 1.0%, respectively).
同义词

——
通路

Metabolic Enzyme/Protease
靶点

Phosphatase
受体

Phosphatase
研究领域

——
适应症

——

CAS Number

515814-01-4
分子量

1214.62
分子式

C63H111N11O12
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : ≥ 50 mg/mL (41.17 mM )
SMILES

[H][C@@]1(CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@]([H])(NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@]([H])([C@H](O)[C@H](C)C\C=C\C=C)N(C)C(=O)[C@]([H])(C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C1=O)C(C)C
化学全称

——

1. Abel MD, et al. ISATX247: a novel calcineurin inhibitor. J Heart Lung Transplant. 2001 Feb;20(2):161.?

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