021-51111890
购物车（）
sales@molnova.cn
MLE-4901
CAS No. 941690-55-7
MLE-4901 ( MLE4901;AZD-2624;AZD2624;Pavinetant )
产品货号. M16736 CAS No. 941690-55-7
A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称MLE-4901
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.
-
产品描述A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia; demonstrates drug-like properties with low metabolic turnover rate in vitro and moderate human plasma protein binding.Schizophrenia Phase 2 Discontinued
-
同义词MLE4901;AZD-2624;AZD2624;Pavinetant
-
通路GPCR/G Protein
-
靶点Neurokinin Receptor
-
受体Neurokinin Receptor
-
研究领域Neurological Disease
-
适应症Schizophrenia
化学信息
-
CAS Number941690-55-7
-
分子量459.56
-
分子式C26H25N3O3S
-
纯度>98% (HPLC)
-
溶解度DMSO : ≥ 50 mg/mL 108.80 mM; H2O : < 0.1 mg/mL
-
SMILESO=C(C1=C(NS(=O)(C)=O)C(C2=CC=CC=C2)=NC3=CC=CC=C13)N[C@H](C4=CC=CC=C4)CC
-
化学全称(S)-3-(methylsulfonamido)-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Li Y, et al. Xenobiotica. 2010 Nov;40(11):721-9.
2. Skorupskaite K, et al. Neuroendocrinology. 2017 Apr 5. doi: 10.1159/000473893.
3. Prague JK, et al. Lancet. 2017 May 6;389(10081):1809-1820.
2. Skorupskaite K, et al. Neuroendocrinology. 2017 Apr 5. doi: 10.1159/000473893.
3. Prague JK, et al. Lancet. 2017 May 6;389(10081):1809-1820.
产品手册
关联产品
-
Neurokinin B
Neurokinin B (NKB) belongs in the family of tachykinin peptides. Neurokinin B is implicated in a variety of human functions and pathways such as the secretion of gonadotropin-releasing hormone.
-
Eledoisin Related Pe...
Eledoisin Related Peptide is a tachykinin receptor ligand and analogue of substance P. ERP can increase spontaneous activity and depolarizing neurons by decreasing membrane conductance.
-
4-Oxoisotretinoin
4-oxo-isotretinoin is the major blood metabolite.
