• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

MLE-4901

CAS No. 941690-55-7

MLE-4901 ( MLE4901;AZD-2624;AZD2624;Pavinetant )

产品货号. M16736 CAS No. 941690-55-7

A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    MLE-4901
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.
  • 产品描述
    A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia; demonstrates drug-like properties with low metabolic turnover rate in vitro and moderate human plasma protein binding.Schizophrenia Phase 2 Discontinued
  • 同义词
    MLE4901;AZD-2624;AZD2624;Pavinetant
  • 通路
    GPCR/G Protein
  • 靶点
    Neurokinin Receptor
  • 受体
    Neurokinin Receptor
  • 研究领域
    Neurological Disease
  • 适应症
    Schizophrenia

化学信息

  • CAS Number
    941690-55-7
  • 分子量
    459.56
  • 分子式
    C26H25N3O3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 50 mg/mL 108.80 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C(C1=C(NS(=O)(C)=O)C(C2=CC=CC=C2)=NC3=CC=CC=C13)N[C@H](C4=CC=CC=C4)CC
  • 化学全称
    (S)-3-(methylsulfonamido)-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Li Y, et al. Xenobiotica. 2010 Nov;40(11):721-9.
2. Skorupskaite K, et al. Neuroendocrinology. 2017 Apr 5. doi: 10.1159/000473893.
3. Prague JK, et al. Lancet. 2017 May 6;389(10081):1809-1820.
产品手册
关联产品
  • [Sar9] Substance P

    [Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.

  • Talnetant

    Talnetant is a selective competitive brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmission.

  • NKP-608

    A non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.