
ML329
CAS No. 19992-50-8
ML329 ( —— )
产品货号. M17416 CAS No. 19992-50-8
ML329 是 MITF 的小分子抑制剂,抑制 TRPM-1 启动子活性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥543 | 有现货 |
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5MG | ¥948 | 有现货 |
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10MG | ¥1596 | 有现货 |
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25MG | ¥3621 | 有现货 |
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50MG | ¥5338 | 有现货 |
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100MG | ¥7606 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称ML329
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述ML329 是 MITF 的小分子抑制剂,抑制 TRPM-1 启动子活性。
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产品描述ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
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体外实验ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with ML329 will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. ML329 shows specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML329 reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, ML329 will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体TRPM-1
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研究领域Others-Field
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适应症——
化学信息
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CAS Number19992-50-8
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分子量328.34
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分子式C16H12N2O4S
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 31 mg/mL; 94.41 mM
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SMILESc1(ccc(cc1)NC1=CC(=O)c2ccccc2C1=O)S(=O)(=O)N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Faloon PW, et al. Bethesda (MD): N/AtioN/Al Center for Biotechnology Information (US); 2010-2012 Dec 13.
产品手册




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