MK2-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MK2-IN-1 是一种有效的、选择性的、非 ATP 竞争性 MAPKAPK2(MK2) 抑制剂，IC50 为 0.11 uM。

MK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2(MK2) inhibitor with IC50 of 0.11 uM; shows excellent kinase selectivity against a broad panel of 150 protein kinases at 10 μM with only on exception of CK1γ3 >50 % inhibition; inhibits pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion; also dose dependently inhibits IL1β-stimulated MMP13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures.

Western Blot Analysis Cell Line:46C mouse embryonic stem cells (mESCs) Concentration:5 μM Incubation Time:0.5, 1, 2, 8 h Result:The Tfcp2l1 protein level gradually increased without a change in the Tfcp2l1 transcript level within 2 h.

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MK2 Inhibitor

MAPK/ERK Signaling

MAPKAPK2 (MK2)

MAPKAPK2 (MK2)

Cancer

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1314118-92-7

472.966

C27H25ClN4O2

>98% (HPLC)

10 mM in DMSO

C1CN(CCN1)C2=CC=C(C=C2)N(CC3=CC=CC=N3)C(=O)C4=CC=C(O4)C5=CC=C(C=C5)Cl

2-Furancarboxamide, 5-(4-chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-

(-20℃)

With Ice Pack

≥ 2 years