MK-8325 ( MK8325 )

产品货号. M11331 CAS No. 1334312-52-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

MK-8325
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively.
产品描述

MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively; also demonstrates potencies comparable to MK-4882 against a panel of mutants in both the GT1a and GT1b backgrounds (GT1a M28V IC50=0.1 nM); demonstrates no cell toxicity with a CC50 >25 uM against Huh-7 replicon cells.HCV Infection Phase 1 Clinical
同义词

MK8325
通路

Microbiology/Virology
靶点

HCV
受体

HCV
研究领域

Infection
适应症

HCV Infection

CAS Number

1334312-52-5
分子量

843.02
分子式

C43H52F2N8O6Si
纯度

>98% (HPLC)
溶解度

——
SMILES

CC(C)C(C(=O)N1CC(CC1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC5=C(C=C4)C6=C(C=C5)NC(=N6)C7C[Si](CN7C(=O)C(C(C)C)NC(=O)OC)(C)C)(F)F)NC(=O)OC
化学全称

methyl ((S)-1-((R)-5-(7-(4-(2-((S)-4,4-difluoro-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)-1H-naphtho[1,2-d]imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

1. Nair AG, et al. Bioorg Med Chem Lett. 2018 Mar 20. pii: S0960-894X(18)30242-7.

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