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MK-4618

CAS No. 1190389-15-1

MK-4618 ( MK 4618;MK4618;Vibegron;KRP-114V;RVT-901 )

产品货号. M10653 CAS No. 1190389-15-1

A potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM; displays no activity for β1 and β2 receptors (EC50>20 uM).

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥5905 有现货
50MG ¥27378 有现货
100MG ¥37260 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    MK-4618
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM; displays no activity for β1 and β2 receptors (EC50>20 uM).
  • 产品描述
    A potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM; displays no activity for β1 and β2 receptors (EC50>20 uM); dose-dependently increases bladder capacity, decreased micturition pressure, and increased bladder compliance in rhesus monkeys, dose-dependently increases the circulating glycerol and fatty acid levels in rhesus and rat in vivo; shows the potential for treatment of overactive bladder with M2/M3 antimuscarinics.Other Indication Phase 3 Clinical
  • 同义词
    MK 4618;MK4618;Vibegron;KRP-114V;RVT-901
  • 通路
    Angiogenesis
  • 靶点
    Adrenergic Receptor
  • 受体
    Adrenergic Receptor
  • 研究领域
    Other Indications
  • 适应症
    Other Disease

化学信息

  • CAS Number
    1190389-15-1
  • 分子量
    444.54
  • 分子式
    C26H28N4O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    O=C([C@@H]1CCC2=NC=CC(N21)=O)NC3=CC=C(C[C@H]4N[C@@H]([C@H](O)C5=CC=CC=C5)CC4)C=C3
  • 化学全称
    (S)-N-(4-(((2S,5R)-5-((R)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Edmondson SD, et al. J Med Chem. 2016 Jan 28;59(2):609-23.
2. Di Salvo J, et al. J Pharmacol Exp Ther. 2017 Feb;360(2):346-355.
产品手册
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