MK-4618
CAS No. 1190389-15-1
MK-4618 ( MK 4618;MK4618;Vibegron;KRP-114V;RVT-901 )
产品货号. M10653 CAS No. 1190389-15-1
A potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM; displays no activity for β1 and β2 receptors (EC50>20 uM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥5905 | 有现货 |
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50MG | ¥27378 | 有现货 |
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100MG | ¥37260 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称MK-4618
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述A potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM; displays no activity for β1 and β2 receptors (EC50>20 uM).
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产品描述A potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM; displays no activity for β1 and β2 receptors (EC50>20 uM); dose-dependently increases bladder capacity, decreased micturition pressure, and increased bladder compliance in rhesus monkeys, dose-dependently increases the circulating glycerol and fatty acid levels in rhesus and rat in vivo; shows the potential for treatment of overactive bladder with M2/M3 antimuscarinics.Other Indication Phase 3 Clinical
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同义词MK 4618;MK4618;Vibegron;KRP-114V;RVT-901
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通路Angiogenesis
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靶点Adrenergic Receptor
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受体Adrenergic Receptor
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number1190389-15-1
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分子量444.54
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分子式C26H28N4O3
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C([C@@H]1CCC2=NC=CC(N21)=O)NC3=CC=C(C[C@H]4N[C@@H]([C@H](O)C5=CC=CC=C5)CC4)C=C3
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化学全称(S)-N-(4-(((2S,5R)-5-((R)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Edmondson SD, et al. J Med Chem. 2016 Jan 28;59(2):609-23.
2. Di Salvo J, et al. J Pharmacol Exp Ther. 2017 Feb;360(2):346-355.
2. Di Salvo J, et al. J Pharmacol Exp Ther. 2017 Feb;360(2):346-355.
产品手册
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