MIDD0301

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MIDD0301 是一种有效的正变构、α5β3γ2 选择性 GABAA 受体 (GABAAR) 配体，EC50 为 17 nM。

MIDD0301 is a potent, positive allosteric, α5β3γ2 selective, GABAA receptor (GABAAR) ligand with EC50 of 17 nM, shows no significant binding at the peripheral GABAAR at 10 uM; causes amplification of GABA induced current mediated by α1-3,5β3γ2 GABAARs in the presence of MIDD0301 in automated patch clamp test; relaxes airway smooth muscle at single micromolar concentrations as demonstrated with ex vivo guinea pig tracheal rings, also attenuates airway hyperresponsiveness (AHR) in an ovalbumin murine model of asthma by oral administration, with low brain distribution; reduces lung cytokine expression of IL-17A, IL-4, and TNF-α, as wells as the number of CD4+ T cells.

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MIDD 0301 | MIDD-0301

Membrane Transporter/Ion Channel

GAT

GAT

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2187489-08-1

414.234

C19H13BrFN3O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (241.41 mM)

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(R)-8-bromo-6-(2-fluorophenyl)-4-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years