021-51111890
购物车（0）
sales@molnova.cn
HZ-166
CAS No. 612527-56-7
HZ-166 ( HZ166 )
产品货号. M15304 CAS No. 612527-56-7
HZ-166 (HZ166) 是一种 GABAA 受体亚型选择性苯二氮卓位点配体，对 α2- 和 α3-GABA(A) 受体具有优先活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
|
| 50MG | ￥16038 | 有现货 |
|
| 100MG | ￥20250 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称HZ-166
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述HZ-166 (HZ166) 是一种 GABAA 受体亚型选择性苯二氮卓位点配体，对 α2- 和 α3-GABA(A) 受体具有优先活性。
-
产品描述HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors; displays a statistically significant higher affinity for receptors not containing the α1 subunit with a rank order of α5 (Ki=140nM) > α2 (Ki=269 nM) > α1 (Ki=382 nM); The Ki value of HZ166 for the α3β3γ2 combination (185± 47 nM) was statistically significantly lower than the Ki value observed for α1β3γ2 but not different from those of α2β3γ2 and α5β3γ2; HZ-166 is antihyperalgesic in mouse models of inflammatory and neuropathic pain.
-
体外实验——
-
体内实验——
-
同义词HZ166
-
通路Membrane Transporter/Ion Channel
-
靶点GAT
-
受体GAT
-
研究领域——
-
适应症——
化学信息
-
CAS Number612527-56-7
-
分子量356.385
-
分子式C21H16N4O2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESO=C(C1=C2N(C=N1)C3=CC=C(C#C)C=C3C(C4=NC=CC=C4)=NC2)OCC
-
化学全称Ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Fischer BD, et al. Neuropharmacology. 2010 Dec;59(7-8):612-8.
2. Di Lio A, et al. Neuropharmacology. 2011 Mar;60(4):626-32.
3. Witkin JM, et al. Neuropharmacology. 2018 Jul 15;137:332-343.
4. Rivas FM, et al. J Med Chem. 2009 Apr 9;52(7):1795-8.
