• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

MID-1

CAS No. 312608-54-1

MID-1 ( —— )

产品货号. M22748 CAS No. 312608-54-1

MID-1 是 MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) 相互作用的抑制剂。它破坏 MG53 与 IRS-1 的分子关联,并消除 MG53 诱导的 IRS-1 泛素化和骨骼肌降解,导致 IRS-1 表达水平升高、胰岛素信号传导和葡萄糖摄取增加。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥1320 有现货
10MG ¥2001 有现货
25MG ¥3686 有现货
50MG ¥5443 有现货
100MG ¥7744 有现货
500MG ¥15552 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    MID-1
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    MID-1 是 MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) 相互作用的抑制剂。它破坏 MG53 与 IRS-1 的分子关联,并消除 MG53 诱导的 IRS-1 泛素化和骨骼肌降解,导致 IRS-1 表达水平升高、胰岛素信号传导和葡萄糖摄取增加。
  • 产品描述
    MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.?It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake.
  • 体外实验
    MID-1 (5 μM; 24 h) increases the IRS-1 expression level in skeletal muscle by disrupting the MG53-IRS-1 interaction.MID-1 (10 μM; 12 h) reduces the luciferase activity in HEK 293 cell line expressing NLUC-IRS-1 and CLUC-C14A.MID-1 (1-20 μM; 12 h) disrupts the MG53-IRS-1 interaction but not MG53-FAK interaction in HEK 293 cells.MID-1 (0.1-10 μM; 4-24 h) abolishes MG53-induced IRS-1 ubiquitination and degradation in HEK 293 cells.MID-1 (5-10 μM; 24 h) increases insulin signaling and insulin-elicited glucose uptake in C2C12 myotubes.MID-1 (5-10 μM; 24 h) enhances skeletal myogenesis.Western Blot Analysis Cell Line:C2C12 myotubes Concentration:5 μM Incubation Time:24 h Result:Increased the IRS-1 protein level.
  • 体内实验
    MID-1 does not have good pharmacokinetics in vivo.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    MG53-IRS-1
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    312608-54-1
  • 分子量
    293.3
  • 分子式
    C12H11N3O4S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:31.25 mg/mL?(106.55 mM;?Need ultrasonic)
  • SMILES
    CCOc1ccc(cc1)C(=O)Nc1ncc(s1)[N+]([O-])=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291(52):26627-26635.
产品手册
关联产品
  • Camelliaside B

    Camelliaside B 具有去糖基化活性。

  • IMR-1

    IMR-1是一类新型Notch抑制剂,针对转录激活,IC50为6 μMol/L。

  • Moth Cytochrome C (M...

    Moth Cytochrome C (MCC) (88-103), derived from the carboxyl terminus of moth cytochrome c, induces positive selection of TCR transgenic thymocytes.This peptide is derived from the carboxyl terminus of moth cytochrome c. Thymic positive and negative selections govern the development of a self-MHC-reactive, yet self-tolerant, T cell repertoire.