Cemiplimab

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cemiplimab (Anti-Human PD-1) 是一种具有高亲和力的程序性死亡受体-1 (PD-1) 单克隆 IgG4 抗体，可阻断 PD-1/PD-L1 介导的 T 细胞抑制。常用于鳞状细胞皮肤癌研究。

Cemiplimab (Anti-Human PD-1) is a high-affinity programmed death receptor-1 (PD-1) monoclonal IgG4 antibody that blocks PD-1/PD-L1-mediated T-cell suppression. Cemiplimab is commonly used in squamous cell skin cancer research.

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Cemiplimab (i.p., 10 mg/kg, five injections within 2 weeks) can increased the proportion of effector T cells in tumors and dLNs to reduce tumor growth by combined immunotherapy with REGN3767 in MC38.Ova tumor mice model.Animal Model:Female human PD-1×LAG-3 knockin mice (8-10 weeks) with MC38.Ova cells Dosage:10 mg/kg Administration:Intraperitoneal injection; five injections within 2 weeks Result:Partially inhibited the growth of MC38.Ova tumors and prolonged the survival of mice by administering alone.Significantly increased the proportion of CD4+ TILs in IFNγ and TNFα by combined immunotherapy with REGN3767.

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Others

Other Targets

Others

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1801342-60-8

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years