Men 10376 ( ——— )

产品货号. M41879 CAS No. 135306-85-3

COA

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HNMR

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MSDS

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产品名称

Men 10376
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Men 10376 是一种有效的选择性的 tachykinin NK-2 受体拮抗剂，对大鼠小肠 NK-2 受体的 Ki 值为 4.4 μM。
产品描述

Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
体外实验

Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats.
体内实验

Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM). Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM).
同义词

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通路

Others
靶点

Other Targets
受体

NK-2 receptor, rat small intestine
研究领域

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适应症

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1. Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36.?

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