Somatostatin-28 a

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Somatostatin-28 (sheep, human rat mouse) 是一种生物活性多肽，在近端肠上皮细胞中合成。Somatostatin-28 (sheep, human rat mouse) 抑制葡萄糖刺激的胰岛素分泌而不影响循环基础胰岛素浓度。Somatostatin-28 (sheep, human rat mouse) 也靶向生长抑素受体 5 亚型 (SSTR5) 调节 GLP-1 分泌。

Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion.

Somatostatin-28 (sheep) (1.1 pmol/kg/min; 通过颈静脉导管静脉注射; 15 min) 抑制 25 μg/kg/min 葡萄糖诱导绵羊胰岛素分泌。Animal Model:Finn-Dorset Horn cross bred sheep (2-5 years old, 70-75 kg) Dosage:1.1 pmol/kg/min for 15 min, with or without 25 μg/kg/min glucose;Administration:Intravenous injection via a jugular catheter;Result:Significantly inhibited insulin secretion, resulted serum concentrations decreasing from about 200 to 150 pmol/L.

Somatostatin-28 剂量依赖地抑制胃泌素释放肽刺激的 GLP-1 分泌，EC50 为 0.01 nM。

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Others

Other Targets

SSTR5

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73032-94-7

3148.56

C137H207N41O39S3

>98% (HPLC)

DMSO : 100 mg/mL (31.76 mM; ultraphonic; )

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(-20℃)

With Ice Pack

≥ 2 years