Dehydrocrenatidine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dehydrocrenatidine 是天然的生物碱，是特异性的 JAK 抑制剂。Dehydrocrenatidine在大鼠神经痛模型中抑制电压门控钠通道并改善机械性异位。

Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain.

Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations.Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation.DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 μM and 4.87 μM, respectively.

Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations.Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation.DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 μM and 4.87 μM, respectively.

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65236-62-6

254.28

C15H14N2O2

>98% (HPLC)

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O(C)C1=C2C=3C(NC2=C(C=C)N=C1)=C(OC)C=CC3

O(C)C1=C2C=3C(NC2=C(C=C)N=C1)=C(OC)C=CC3

(-20℃)

With Ice Pack

≥ 2 years