Big Endothelin-1 fragment (22-38) (human)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Big Endothelin-1 (22-38), human 是由人源的大内皮素 1 (ET-1) 的 22-38 片段 (1-38)。大内皮素 1 (1-38) 是 ET-1 的前肽，具有强大而持久的血管收缩作用，其 38 个氨基酸链发生特定的酶切，形成内皮素 1 (1-21) 和 C 端片段大内皮素 1 (22-38)。

Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38).

Big Endothelin-1 (22-38), human (3 nM/kg; intra-arterial injection; single dose) produces a significant rise in left ventricular systolic pressure (LVSP) in anesthetized rabbits, and is enhanced by cyclooxygenase inhibitor Indomethacin (5 mg/kg i.v.) significantly.Big Endothelin-1 (22-38), human (3 nM/kg; intravascular method; single dose), has no antiaggregatory properties for platelet induced by ADP in rabbits.

Big Endothelin-1 (22-38), human (0.1 μM; 30 min) induces the release of prostacyclin (PGI2) from rabbit, guinea pig, and rat lungs.

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Others

Other Targets

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124932-61-2

1809.03

C80H125N23O25

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years