Dieugenol ( 去氢双丁香酚 )

产品货号. M39031 CAS No. 4433-08-3

COA

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产品名称

Dieugenol
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities.
产品描述

Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.
体外实验

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体内实验

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同义词

去氢双丁香酚
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靶点

Other Targets
受体

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研究领域

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适应症

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1. Ogata, et al. Antioxidant activity of eugenol and related monomeric and dimeric compounds. Chem. Pharm. Bull. (Tokyo) 48(10), 1467-1469 (2000).

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