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Ademetionine(b)
CAS No. 29908-03-0
Ademetionine(b) ( S-Adenosyl-L-methionine | S-Adenosyl methionine | SAMe | AdoMet )
产品货号. M20824 CAS No. 29908-03-0
腺苷蛋氨酸是蛋氨酸的中间代谢产物，用于治疗原发性胆汁性肝硬化和重度抑郁症。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥253 | 有现货 |
|
| 10MG | ￥360 | 有现货 |
|
| 25MG | ￥635 | 有现货 |
|
| 50MG | ￥953 | 有现货 |
|
| 100MG | ￥1383 | 有现货 |
|
| 200MG | ￥2075 | 有现货 |
|
| 500MG | ￥3112 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Ademetionine(b)
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述腺苷蛋氨酸是蛋氨酸的中间代谢产物，用于治疗原发性胆汁性肝硬化和重度抑郁症。
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产品描述Ademetionine is an intermediate metabolite of methioninefor treatment of primary biliary cirrhosis and major depressive disorder.
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体外实验Apoptosis Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)Result:Showed an approximately 10% and 3%of apoptotic cells respectively.Cell Cycle Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)Result:Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
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体内实验Animal Model:Valproic acid treated young mice Dosage:30?mg/kg Administration:p.o., for 3 days Result:Alleviated most ASD like neurobehavioral symptoms.Normalized the redox potential in the prefrontal cortex.
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同义词S-Adenosyl-L-methionine | S-Adenosyl methionine | SAMe | AdoMet
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通路Others
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靶点Other Targets
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受体Others
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研究领域Neurological Disease
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适应症Major depressive disorder
化学信息
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CAS Number29908-03-0
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分子量398.44
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分子式C15H22N6O5S
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (250.98 mM);H2O:43 mg/mL (107.92 mM)
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SMILESC[S+](CCC(N)C(=O)[O-])CC1OC(n2cnc3c(N)ncnc32)C(O)C1O
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化学全称(2S)-2-amino-4-((((2S3S4R5R)-5-(6-amino-9H-purin-9-yl)-34-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonio)butanoate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ivashkin V T Maevskaya M V Kobalava Z D et al. Open-label study of ademetionine for the treatment of intrahepatic cholestasis associated with alcoholic liver disease.[J]. Minerva Gastroenterologica E Dietologica 2018.
产品手册
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