Ademetionine(b)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

腺苷蛋氨酸是蛋氨酸的中间代谢产物，用于治疗原发性胆汁性肝硬化和重度抑郁症。

Ademetionine is an intermediate metabolite of methioninefor treatment of primary biliary cirrhosis and major depressive disorder.

Apoptosis Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)Result:Showed an approximately 10% and 3%of apoptotic cells respectively.Cell Cycle Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)Result:Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.

Animal Model:Valproic acid treated young mice Dosage:30?mg/kg Administration:p.o., for 3 days Result:Alleviated most ASD like neurobehavioral symptoms.Normalized the redox potential in the prefrontal cortex.

S-Adenosyl-L-methionine | S-Adenosyl methionine | SAMe | AdoMet

Others

Other Targets

Others

Neurological Disease

Major depressive disorder

29908-03-0

398.44

C15H22N6O5S

>98% (HPLC)

DMSO:100 mg/mL (250.98 mM);H2O:43 mg/mL (107.92 mM)

C[S+](CCC(N)C(=O)[O-])CC1OC(n2cnc3c(N)ncnc32)C(O)C1O

(2S)-2-amino-4-((((2S3S4R5R)-5-(6-amino-9H-purin-9-yl)-34-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonio)butanoate

(-20℃)

With Ice Pack

≥ 2 years