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Lactic acid
CAS No. 50-21-5
Lactic acid ( —— )
产品货号. M37801 CAS No. 50-21-5
Lactate (Lactic Acid) 是一种羟基羧酸受体 1 (HCAR1) 激活剂和诱导赖氨酸残基乳酰化的表观遗传调节剂。Lactate 是糖酵解终产物，弥补了糖酵解和氧化磷酸化之间的差距。Lactate 是一种肿瘤代谢物，在抗肿瘤免疫中具有乳酸的免疫保护作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥140 | 有现货 |
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| 25MG | ￥201 | 有现货 |
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| 50MG | ￥277 | 有现货 |
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| 100MG | ￥381 | 有现货 |
|
| 500MG | ￥608 | 有现货 |
|
| 1G | ￥890 | 有现货 |
|
生物学信息
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产品名称Lactic acid
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Lactate (Lactic Acid) 是一种羟基羧酸受体 1 (HCAR1) 激活剂和诱导赖氨酸残基乳酰化的表观遗传调节剂。Lactate 是糖酵解终产物，弥补了糖酵解和氧化磷酸化之间的差距。Lactate 是一种肿瘤代谢物，在抗肿瘤免疫中具有乳酸的免疫保护作用。
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产品描述Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity.
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体外实验Cell Proliferation Assay Cell Line:Uveal melanoma 92.1 cells Concentration:20 mM Incubation Time:24, 48 h Result:Inhibited cell proliferation and migration.Western Blot Analysis Cell Line:Uveal melanoma cells Concentration:20 mM Incubation Time:24 h Result:Showed an increase in the protein expression levels of MCT1 and HCAR1 Western Blot Analysis Cell Line:Uveal melanoma cells Concentration:20 mM Incubation Time:24 h Result:Induced a significant increase in mRNA expression levels of SLC16A1 and HCAR1.
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体内实验Animal Model:Female C57BL/6 mice with MC38 colon cancer cells Dosage:1.6 g/kg Administration:Subcutaneous; daily from Day 8 to 30 days Result:Significantly suppressed tumor growth.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number50-21-5
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分子量90.08
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分子式C3H6O3
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纯度>98% (HPLC)
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溶解度In Vitro:?H2O 中的溶解度 : 100 mg/mL (1110.12 mM; 超声助溶) DMSO 中的溶解度 : 100 mg/mL (1110.12 mM; 超声助溶 )
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SMILESCC(O)C(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24(1):24.?
产品手册
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