Harringtonine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

三尖杉酯碱是一种天然三尖杉生物碱，可抑制蛋白质合成。

Harringtonine a natural Cephalotaxus alkaloid inhibits protein synthesis.(In Vitro):Harringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation. Harringtonine displays potent inhibition of Chikungunya virus infection with an EC50 of 0.24 μM. Harringtonine could inhibit other alphaviruses. Harringtonine inhibits the growth of human myeloid leukemia cells in vitro at low concentrations. The mechanism of the antitumor action of harringtonine is considered to be an effect on protein synthesis and is characterized by breakdown of polysomes to monosomes.

Harringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation. Harringtonine displays potent inhibition of Chikungunya virus infection with an EC50 of 0.24 μM. Harringtonine could inhibit other alphaviruses. Harringtonine inhibits the growth of human myeloid leukemia cells in vitro at low concentrations. The mechanism of the antitumor action of harringtonine is considered to be an effect on protein synthesis and is characterized by breakdown of polysomes to monosomes.

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Others

Other Targets

Others

cancer

Leukemia

26833-85-2

531.59

C28H37NO9

>98% (HPLC)

DMSO:1 mg/mL (188.11 mM)

CC(C)(CC[C@@](CC(=O)OC)(C(=O)O[C@H]1[C@H]2C3=CC4=C(C=C3CCN5[C@@]2(CCC5)C=C1OC)OCO4)O)O

1-((1S3aR14bS)-2-methoxy-1568914b-hexahydro-4H-[13]dioxolo[4'5':45]benzo[12-d]cyclopenta[b]pyrrolo[12-a]azepin-1-yl) 4-methyl (R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)succinate

(-20℃)

With Ice Pack

≥ 2 years