G43

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

G43 是一种有效的选择性 glucosyltransferase抑制剂，对 GtfB 和 GtfC 的Kd 值分别为3.7 μM和46.9 nM。G43 在体内外具有抗变形链球菌 (S. mutans) 的作用，可用于龋齿研究。

G43 is a potent, selective glucosyltransferaseinhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study.

RT-PCR Cell Line:S. mutans. UA159 cells Concentration:3.125, 6.25, 12, 25 μM Incubation Time:24 h Result:Showed no significant difference on expression of gtfs (gtfB, gtfC and gtfD).

Animal Model:The rat model of dental caries infected with S. mutans UA159 Dosage:100?μM twice daily for 4 weeks Administration:Topically administration Result:Reduced the buccal, sulcal, and proximal surface caries scores, but did not lose weight over the course of the study.

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Metabolic Enzyme/Protease

Transferase

Transferase | Antibacterial

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690693-02-8

341.34

C16H11N3O4S

>98% (HPLC)

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C(NC1=C(C(N)=O)C=CC=C1)(=O)C2=CC=3C(S2)=CC=C(N(=O)=O)C3

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(-20℃)

With Ice Pack

≥ 2 years