AOH1996 ( —— )

产品货号. M36932 CAS No. 2089314-64-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AOH1996
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
产品描述

AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
体外实验

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体内实验

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同义词

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通路

Apoptosis
靶点

Apoptosis
受体

Apoptosis | DNA
研究领域

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适应症

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计算器

产品手册

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