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Carotuximab
CAS No. 1268714-50-6
Carotuximab ( —— )
产品货号. M36777 CAS No. 1268714-50-6
Carotuximab (TRC105) 是一种 IgG1 单克隆抗体，可阻断内皮糖蛋白 (CD105) 及其下游 Smad 信号通路。Carotuximab 具有免疫调节和抗肿瘤作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥4722 | 有现货 |
|
| 10MG | ￥6536 | 有现货 |
|
| 25MG | ￥9179 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Carotuximab
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Carotuximab (TRC105) 是一种 IgG1 单克隆抗体，可阻断内皮糖蛋白 (CD105) 及其下游 Smad 信号通路。Carotuximab 具有免疫调节和抗肿瘤作用。
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产品描述Carotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions.
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体外实验Western Blot Analysis Cell Line:Human aortic endothelial cells (HAoECs) Concentration:300 μg/mL Incubation Time:Pretreatment 1 h, and then co-cultured for 12 h Result:Reduced the 7-Ketocholesterol-induced Eng protein levels and pSmad1/5 and pSmad2/3 signaling.
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体内实验Animal Model:Female NSG (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ; 7-8 weeks) injected with primary AML-0032 cells Dosage:2 mg/kg Administration:i.v; every 3 days; for 8 weeks Result:Along with Decitabine resulted in a more durable anti-leukemic effect in AML xenografts.
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同义词——
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通路Others
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靶点Other Targets
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受体TGF-beta/Smad | Immunology/Inflammation related
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研究领域——
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适应症——
化学信息
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CAS Number1268714-50-6
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分子量
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分子式——
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Katarina Tripska , et al. Monoclonal anti-endoglin antibody TRC105 (carotuximab) prevents hypercholesterolemia and hyperglycemia-induced endothelial dysfunction in human aortic endothelial cells. Front Med (Lausanne). 2022 Sep 7;9:845918.?
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