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Sincalide ammonium
CAS No. 70706-98-8
Sincalide ammonium ( Cholecystokinin octapeptide ammonium; CCK-8 ammonium; SQ19844 ammonium )
产品货号. M29897 CAS No. 70706-98-8
Sincalide ammonium (Cholecystokinin octapeptide ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2366 | 有现货 |
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| 10MG | ￥3791 | 有现货 |
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| 25MG | ￥5840 | 有现货 |
|
| 50MG | ￥7896 | 有现货 |
|
| 100MG | ￥10170 | 有现货 |
|
| 500MG | ￥20610 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Sincalide ammonium
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Sincalide ammonium (Cholecystokinin octapeptide ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography.
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产品描述Sincalide ammonium (Cholecystokinin octapeptide ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography.
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体外实验Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium), as a novel cardiovascular hormone, has a significant inhibitory effect on myocardial fibrosis in noninfarcted areas. Sincalide ammonium also plays a positive role in fighting inflammation, apoptosis and collagen deposition. CCK‐8 (ammonium) protects H9c2 cardiomyoblasts from Ang II‐induced apoptosis partly via activation of the CCK1 receptor and the phosphatidyqinositol‐3 kinase/protein kinase B (PI3K/Akt) signaling pathway. Cell Viability Assaysup>Cell Line:H9c2 cells Concentration:0.001, 0.01, 0.1, 1, 10, or 100 μmol/L Incubation Time:24 h Result:Attenuated Ang II‐induced toxicity in H9c2 cells Apoptosis Analysis Cell Line:H9c2 cells Concentration:0.001, 0.01, 0.1, 1, 10, or 100 μmol/L Incubation Time:24 h Result:Decreased apoptotic cells, and prevented Ang II‐induced cytotoxicity that involves modulation of the PI3K/Akt pathway.Western Blot Analysis Cell Line:H9c2 cells Concentration:0.001, 0.01, 0.1, 1, 10, or 100 μmol/L Incubation Time:24 h Result:Expressed the protein and mRNAs of CCK and both its receptors in H9c2 cells.RT-PCR Cell Line:H9c2 cells Concentration:0.001, 0.01, 0.1, 1, 10, or 100 μmol/L Incubation Time:24 h Result:Increased the protein and mRNA expression levels of CCK and decreased CCK 1 receptor expression levels at both the protein and mRNA levels with Ang II stimulation markedly.
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体内实验Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium) alleviates fibrosis in the noninfarcted regions and delay the left ventricular remodeling and the progress of heart failure in a MI rat model. Animal Model:MI rat modelDosage:50 μg/kg Administration:i.p.; 50 μg/kg/d; for 4 weeks Result:Had significant inhibitory effect on myocardial fibrosis in noninfarcted areas.
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同义词Cholecystokinin octapeptide ammonium; CCK-8 ammonium; SQ19844 ammonium
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number70706-98-8
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分子量1160.3
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分子式C49H65N11O16S3
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纯度>98% (HPLC)
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溶解度H2O : 12.5 mg/mL (10.77 mM; Need ultrasonic)
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SMILES——
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化学全称Sequence:Asp-{SO3H-Tyr}-Met-Gly-Trp-Met-Asp-Phe-NH2
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
Maher KA. Kinevac (sincalide for injection)/Squibb Diagnostics. Gastroenterol Nurs. 1991 Oct;14(2):98-100.
产品手册
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