Mogamulizumab

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Mogamulizumab (KW-0761) 是一种重组 抗 CCR4 单克隆抗体 (MAb)。Mogamulizumab 可以通过抗体依赖性细胞毒性 (ADCC) 消除肿瘤细胞。Mogamulizumab 可用于癌症、成人T细胞白血病/淋巴瘤 (ATLL)、皮肤T细胞淋巴瘤 (CTCL) 的研究。

Mogamulizumab (KW-0761) is a recombinant anti-CCR4 monoclonal antibody (MAb). Mogamulizumab can eliminate tumor cells by antibody-dependent cellular cytotoxicity (ADCC). Mogamulizumab can be used in the research of cancers, adult T-cell leukemia/lymphoma (ATLL), cutaneous T-cell lymphoma (CTCL).

Mogamulizumab (10 μg/mL, 24 h) induces ADCC activity against CCR4-positive cell lines (SNT8, SNT16, SNK6, and KAI3) in the presence of PBMCs.Mogamulizumab (10 μg/mL, 3 days) reduces the human T-lymphotropic virus type 1 (HTLV-1) proviral load and inhibits spontaneous proliferation in PBMCs from patients with HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP).Mogamulizumab (1 μg/mL, 5 days) eliminates the CD4+CCR4+ T cells in cultured PBMCs from patients with HAM/TSP.

Mogamulizumab (1 mg/kg, i.p., twice per week for 4 weeks) together with PBMC transplantation inhibits the growth of EBV-positive NK-cell lymphomas in a murine xenograft model.Mogamulizumab (0.1 mg/kg, i.v., every other day) together with canine PBMCs (every fourth day)), inhibits tumor growth in canine bladder cancer-engrafted mouse model.Mogamulizumab (0.01-1 mg/kg, i.v.) reduces circulating CD4+CCR4+ T cells, with no adverse effect in dogs.Animal Model:Murine xenograft model, constructed by using the immunodeficient NOG mouse and the EBV-positive NK-cell lymphoma cell line (SNK6)Dosage:1 mg/kg Administration: Intraperitoneal injection (i.p.), together with PBMC transplantation; twice per week for 4 weeks.Result:Suppressed Tumor growth with vacuolar degeneration.

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Autophagy

CXCR

CXCR

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1159266-37-1

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years