CHIR98014 ( CHIR98014 | CHIR-98014 | CHIR 98014 )

产品货号. M17541 CAS No. 556813-39-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CHIR98014
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CHIR 98014 是一种有效的 GSK-3α/β 抑制剂，在无细胞测定中 IC50 为 0.65 nM/0.58 nM，能够区分 GSK-3 与其最接近的同源物 Cdc2 和 ERK2。
产品描述

CHIR98014, also known as CT-98024, is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively). It is inactive against a series of other serine/threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.
体外实验

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体内实验

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同义词

CHIR98014 | CHIR-98014 | CHIR 98014
通路

Autophagy
靶点

CXCR
受体

GSK-3α/β| p70 S6K
研究领域

Cancer
适应症

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CAS Number

556813-39-9
分子量

486.31
分子式

C20H17Cl2N9O2
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 125 mg/mL (257.04 mM)
SMILES

c1cc(c(cc1Cl)Cl)c1nc(ncc1c1[nH]ccn1)NCCNc1nc(c(cc1)[N+](=O)[O-])N
化学全称

N2-(2-((4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)-5-nitropyridine-2,6-diamine

1. Ring DB,et al. Diabetes. 2003, 52(3), 588-595.

计算器

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