Risankizumab

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Risankizumab (BI 655066) 是一种人源化 IgG 单克隆抗体，靶向 IL-23 p19 亚基(Kd <10 pM)，并能抑制人 IL-23 在小鼠脾细胞中诱导的 IL-17 产生(IC50 = 2 pM)。Risankizumab 可用于研究免疫性和炎症性疾病，如寻常型银屑病、银屑病关节炎、广泛性脓疱型银屑病和红皮病型银屑病。

Risankizumab (BI 655066) is a humanised IgG monoclonal antibody, targeting IL-23 p19 subunit (Kd <10 pM) and inhibiting IL-17 production induced by human IL-23 in mouse splenocytes (IC50 = 2 pM). Risankizumab can be used to research immunological and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis and erythrodermic psoriasis.

Risankizumab (BI 655066) has a high affinity for human and cynomolgus IL23 with Kds <10 pM.Risankizumab (BI 655066) inhibits endogenous (THP-1 cell generated) human IL23-induced and recombinant cynomolgus IL23-induced IL17 production with IC50s of 2 pM and 17 pM, respectively.

Risankizumab (BI 655066) (1 mg/kg; i.p.; single dosage) inhibits IL23-induced mice ear swelling and cytokine production.Animal Model:Mice (injected with BI 655066, 1 h later injected recombinant human IL23 into the skin of the mouse ear for 4 days) Dosage:1 mg/kg Administration:i.p.; single dosage Result:Significantly inhibited IL23-induced ear swelling and cytokine production.Animal Model:Cynomolgus monkeys Dosage:1.0 mg/kg Administration:i.v. or s.c.Result:Pharmacokinetic Parameters of Risankizumab (BI 655066) in cynomolgus monkeys.

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Apoptosis

IL Receptor

IL Receptor

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1612838-76-2

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years